News 

2024 NATURE CONFERENCE - Boston, US

Shared Neoantigens For Colorectal Cancer Patients

Our study highlights the potential application of an off-the-shelf neoantigen panel to speed up the identification of immunogenic neoantigens and corresponding TCR constructs for cancer vaccine development.

LINK

2024 NATURE CONFERENCE - Boston, US

Enhancing Neoantigen Prioritization in Through T-Cell Receptor Repertoire Profiling

Our study highlight benefit of integrating T-cell receptor (TCR) repertoire profiles of tumor-infiltrating lymphocytes (TILs) as a key determinant of immunogenicity into neoantigen prediction and prioritization workflow. 

LINK

ESMO Asia Congress 2023

Identification of Recurrent Neoantigens for the Development of Off-the-shelf Cancer Vaccines

We have developed a pipeline with both computational prediction tools and experimental validation assays, known as NEX-NEO to expedite the identification of immunogenic public neoantigens

LINK

ESMO Asia Congress 2023

T- Cell Receptor Repertoire Profiles of Tumor Infiltrating Lymphocytes Improves Neoantigen Prioritization

We integrate T-cell receptor (TCR) repertoire profiles of tumor-infiltrating lymphocytes (TILs) as a key determinant of immunogenicity into neoantigen prediction and prioritization

LINK

Publications

Frontiers in Immunology

Improvement in neoantigen prediction via integration of RNA sequencing data for variant calling

LINK

Bioinfomatics (iSCB)

epiTCR: a highly sensitive predictor for TCR–peptide binding

LINK